Lịch sử đối đầu Tottenham Hotspur vs Southampton |
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| 10.02.2022 | Tottenham Hotspur | 2-3 | Southampton |  | |
| 28.12.2021 | Southampton | 1-1 | Tottenham Hotspur | | |
Phong độ của Tottenham Hotspur |
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| 22.05.2022 | Norwich City | 0-5 | Tottenham Hotspur | | ||
| 15.05.2022 | Tottenham Hotspur | 1-0 | Burnley | | ||
| 13.05.2022 | Tottenham Hotspur | 3-0 | Arsenal | | ||
| 08.05.2022 | Liverpool | 1-1 | Tottenham Hotspur | | ||
| 01.05.2022 | Tottenham Hotspur | 3-1 | Leicester City | | ||
| 23.04.2022 | Brentford | 0-0 | Tottenham Hotspur | | ||
| 16.04.2022 | Tottenham Hotspur | 0-1 | Brighton Hove Albion | | ||
| 09.04.2022 | Aston Villa | 0-4 | Tottenham Hotspur | | ||
| 03.04.2022 | Tottenham Hotspur | 5-1 | Newcastle United | | ||
| 20.03.2022 | Tottenham Hotspur | 3-1 | West Ham United | | ||
Phong độ của Southampton |
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| 22.05.2022 | Leicester City | 4-1 | Southampton | | ||
| 18.05.2022 | Southampton | 1-2 | Liverpool | | ||
| 07.05.2022 | Brentford | 3-0 | Southampton | | ||
| 30.04.2022 | Southampton | 1-2 | Crystal Palace | | ||
| 24.04.2022 | Brighton Hove Albion | 2-2 | Southampton | | ||
| 22.04.2022 | Burnley | 2-0 | Southampton | | ||
| 16.04.2022 | Southampton | 1-0 | Arsenal | | ||
| 09.04.2022 | Southampton | 0-6 | Chelsea | | ||
| 02.04.2022 | Leeds United | 1-1 | Southampton | | ||
| 13.03.2022 | Southampton | 1-2 | Watford | | ||