Lịch sử đối đầu Tottenham Hotspur vs Southampton |
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| 28.12.2021 | Southampton | 1-1 | Tottenham Hotspur |  | |
Phong độ của Tottenham Hotspur |
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| 23.01.2022 | Chelsea | 2-0 | Tottenham Hotspur | | ||
| 20.01.2022 | Leicester City | 2-3 | Tottenham Hotspur | | ||
| 01.01.2022 | Watford | 0-1 | Tottenham Hotspur | | ||
| 28.12.2021 | Southampton | 1-1 | Tottenham Hotspur | | ||
| 26.12.2021 | Tottenham Hotspur | 3-0 | Crystal Palace | | ||
| 19.12.2021 | Tottenham Hotspur | 2-2 | Liverpool | | ||
| 05.12.2021 | Tottenham Hotspur | 3-0 | Norwich City | | ||
| 03.12.2021 | Tottenham Hotspur | 2-0 | Brentford | | ||
| 21.11.2021 | Tottenham Hotspur | 2-1 | Leeds United | | ||
| 07.11.2021 | Everton | 0-0 | Tottenham Hotspur | | ||
Phong độ của Southampton |
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| 23.01.2022 | Southampton | 1-1 | Manchester City | | ||
| 15.01.2022 | Wolves | 3-1 | Southampton | | ||
| 12.01.2022 | Southampton | 4-1 | Brentford | | ||
| 28.12.2021 | Southampton | 1-1 | Tottenham Hotspur | | ||
| 26.12.2021 | West Ham United | 2-3 | Southampton | | ||
| 16.12.2021 | Crystal Palace | 2-2 | Southampton | | ||
| 11.12.2021 | Arsenal | 3-0 | Southampton | | ||
| 04.12.2021 | Southampton | 1-1 | Brighton Hove Albion | | ||
| 02.12.2021 | Southampton | 2-2 | Leicester City | | ||
| 27.11.2021 | Liverpool | 4-0 | Southampton | | ||