Lịch sử đối đầu Southampton vs Manchester United |
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| 12.02.2022 | Manchester United | 1-1 | Southampton |  | |
| 22.08.2021 | Southampton | 1-1 | Manchester United | | |
Phong độ của Southampton |
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| 20.08.2022 | Leicester City | 1-2 | Southampton | | ||
| 13.08.2022 | Southampton | 2-2 | Leeds United | | ||
| 06.08.2022 | Tottenham Hotspur | 4-1 | Southampton | | ||
| 22.05.2022 | Leicester City | 4-1 | Southampton | | ||
| 18.05.2022 | Southampton | 1-2 | Liverpool | | ||
| 07.05.2022 | Brentford | 3-0 | Southampton | | ||
| 30.04.2022 | Southampton | 1-2 | Crystal Palace | | ||
| 24.04.2022 | Brighton Hove Albion | 2-2 | Southampton | | ||
| 22.04.2022 | Burnley | 2-0 | Southampton | | ||
| 16.04.2022 | Southampton | 1-0 | Arsenal | | ||
Phong độ của Manchester United |
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| 23.08.2022 | Manchester United | 2-1 | Liverpool | | ||
| 13.08.2022 | Brentford | 4-0 | Manchester United | | ||
| 07.08.2022 | Manchester United | 1-2 | Brighton Hove Albion | | ||
| 22.05.2022 | Crystal Palace | 1-0 | Manchester United | | ||
| 07.05.2022 | Brighton Hove Albion | 4-0 | Manchester United | | ||
| 03.05.2022 | Manchester United | 3-0 | Brentford | | ||
| 29.04.2022 | Manchester United | 1-1 | Chelsea | | ||
| 23.04.2022 | Arsenal | 3-1 | Manchester United | | ||
| 20.04.2022 | Liverpool | 4-0 | Manchester United | | ||
| 16.04.2022 | Manchester United | 3-2 | Norwich City | | ||