Lịch sử đối đầu Southampton vs Manchester City |
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| 18.09.2021 | Manchester City | 0-0 | Southampton |  | |
Phong độ của Southampton |
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| 15.01.2022 | Wolves | 3-1 | Southampton | | ||
| 12.01.2022 | Southampton | 4-1 | Brentford | | ||
| 28.12.2021 | Southampton | 1-1 | Tottenham Hotspur | | ||
| 26.12.2021 | West Ham United | 2-3 | Southampton | | ||
| 16.12.2021 | Crystal Palace | 2-2 | Southampton | | ||
| 11.12.2021 | Arsenal | 3-0 | Southampton | | ||
| 04.12.2021 | Southampton | 1-1 | Brighton Hove Albion | | ||
| 02.12.2021 | Southampton | 2-2 | Leicester City | | ||
| 27.11.2021 | Liverpool | 4-0 | Southampton | | ||
| 20.11.2021 | Norwich City | 2-1 | Southampton | | ||
Phong độ của Manchester City |
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| 15.01.2022 | Manchester City | 1-0 | Chelsea | | ||
| 01.01.2022 | Arsenal | 1-2 | Manchester City | | ||
| 30.12.2021 | Brentford | 0-1 | Manchester City | | ||
| 26.12.2021 | Manchester City | 6-3 | Leicester City | | ||
| 19.12.2021 | Newcastle United | 0-4 | Manchester City | | ||
| 15.12.2021 | Manchester City | 7-0 | Leeds United | | ||
| 11.12.2021 | Manchester City | 1-0 | Wolves | | ||
| 05.12.2021 | Watford | 1-3 | Manchester City | | ||
| 02.12.2021 | Aston Villa | 1-2 | Manchester City | | ||
| 28.11.2021 | Manchester City | 2-1 | West Ham United | | ||