Lịch sử đối đầu Southampton vs Arsenal |
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| 11.12.2021 | Arsenal | 3-0 | Southampton |  | |
Phong độ của Southampton |
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| 09.04.2022 | Southampton | 0-6 | Chelsea | | ||
| 02.04.2022 | Leeds United | 1-1 | Southampton | | ||
| 13.03.2022 | Southampton | 1-2 | Watford | | ||
| 11.03.2022 | Southampton | 1-2 | Newcastle United | | ||
| 05.03.2022 | Aston Villa | 4-0 | Southampton | | ||
| 26.02.2022 | Southampton | 2-0 | Norwich City | | ||
| 19.02.2022 | Southampton | 2-0 | Everton | | ||
| 12.02.2022 | Manchester United | 1-1 | Southampton | | ||
| 10.02.2022 | Tottenham Hotspur | 2-3 | Southampton | | ||
| 23.01.2022 | Southampton | 1-1 | Manchester City | | ||
Phong độ của Arsenal |
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| 09.04.2022 | Arsenal | 1-2 | Brighton Hove Albion | | ||
| 05.04.2022 | Crystal Palace | 3-0 | Arsenal | | ||
| 19.03.2022 | Aston Villa | 0-1 | Arsenal | | ||
| 17.03.2022 | Arsenal | 0-2 | Liverpool | | ||
| 13.03.2022 | Arsenal | 2-0 | Leicester City | | ||
| 06.03.2022 | Watford | 2-3 | Arsenal | | ||
| 25.02.2022 | Arsenal | 2-1 | Wolves | | ||
| 19.02.2022 | Arsenal | 2-1 | Brentford | | ||
| 11.02.2022 | Wolves | 0-1 | Arsenal | | ||
| 23.01.2022 | Arsenal | 0-0 | Burnley | | ||