Lịch sử đối đầu Manchester United vs Southampton |
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| 22.08.2021 | Southampton | 1-1 | Manchester United |  | |
Phong độ của Manchester United |
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| 09.02.2022 | Burnley | 1-1 | Manchester United | | ||
| 22.01.2022 | Manchester United | 1-0 | West Ham United | | ||
| 20.01.2022 | Brentford | 1-3 | Manchester United | | ||
| 16.01.2022 | Aston Villa | 2-2 | Manchester United | | ||
| 04.01.2022 | Manchester United | 0-1 | Wolves | | ||
| 31.12.2021 | Manchester United | 3-1 | Burnley | | ||
| 28.12.2021 | Newcastle United | 1-1 | Manchester United | | ||
| 12.12.2021 | Norwich City | 0-1 | Manchester United | | ||
| 05.12.2021 | Manchester United | 1-0 | Crystal Palace | | ||
| 03.12.2021 | Manchester United | 3-2 | Arsenal | | ||
Phong độ của Southampton |
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| 10.02.2022 | Tottenham Hotspur | 2-3 | Southampton | | ||
| 23.01.2022 | Southampton | 1-1 | Manchester City | | ||
| 15.01.2022 | Wolves | 3-1 | Southampton | | ||
| 12.01.2022 | Southampton | 4-1 | Brentford | | ||
| 28.12.2021 | Southampton | 1-1 | Tottenham Hotspur | | ||
| 26.12.2021 | West Ham United | 2-3 | Southampton | | ||
| 16.12.2021 | Crystal Palace | 2-2 | Southampton | | ||
| 11.12.2021 | Arsenal | 3-0 | Southampton | | ||
| 04.12.2021 | Southampton | 1-1 | Brighton Hove Albion | | ||
| 02.12.2021 | Southampton | 2-2 | Leicester City | | ||